Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic.
Department of Neuroscience, Lerner Research Institute, Cleveland Clinic.
Ann Neurol. 2017 Oct;82(4):635-639. doi: 10.1002/ana.25019. Epub 2017 Sep 21.
Detecting cortical demyelination in patients with multiple sclerosis (MS) is difficult. Using magnetic resonance imaging (MRI), ratio maps of T1-weighted (T1w) and T2-weighted (T2w) images may be sensitive to cortical myelin levels. In this MRI-histological study, postmortem in situ scans were acquired from 6 cadavers with MS on a 3T MRI machine. Immunocytochemistry was used to correlate myelin status and cortical T1w/T2w measures. The results showed that the T1w/T2w values significantly differed between demyelinated and myelinated cortex (p < 0.001). The T1w/T2w ratio maps may be a relatively simple, clinically feasible method to assess cortical demyelination. Ann Neurol 2017;82:635-639.
在多发性硬化症（MS）患者中检测皮质脱髓鞘较困难。使用磁共振成像（MRI），T1 加权（T1w）和 T2 加权（T2w）图像的比值图可能对皮质髓鞘水平敏感。在这项 MRI-组织学研究中，对 6 例 MS 尸检标本在 3T MRI 机器上进行了原位扫描。免疫细胞化学用于相关性髓鞘状态和皮质 T1w/T2w 测量。结果表明，脱髓鞘和髓鞘化皮质之间 T1w/T2w 值有显著差异（p<0.001）。T1w/T2w 比值图可能是一种相对简单、临床上可行的评估皮质脱髓鞘的方法。Ann Neurol 2017;82:635-639.
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