Department of Dermatology, Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Besançon University Hospital, Besançon, France.
INSERM UMR1098, SFR FED 4234 IBCT, University of Franche-Comté, Besançon, France.
J Eur Acad Dermatol Venereol. 2018 Feb;32(2):323-328. doi: 10.1111/jdv.14525. Epub 2017 Sep 5.
Bateman purpura is characterized by diffuse senile skin atrophy, senile purpura and spontaneous stellar pseudocicatrices. Cutaneous changes in the course of ageing have been related to lower levels of ascorbic acid into the dermis of elderly people.
In this study, we postulate that senile purpura could be linked to dermal vitamin C deficiency and could be corrected by topical administration of this vitamin.
A 12-weeks, hemi-member (forearm or leg), randomized double-blind comparative study was conducted in 18 patients with Bateman purpura aged over than 60 years. At each visit, clinical assessment and biometrological measurements were performed. Clinical examination and scoring by experts showed a significant improvement on the vitamin C-treated side compared with the control, with reduction of haemorrhage areas, increase of dermal thickness.
Twice-daily application of 5% topical vitamin C led to a clinically apparent improvement of the skin symptoms and allows beneficial effects on skin elasticity and thickness. Bateman purpura, a classical sign of photoaging whose origin has not clearly been recognized could be improved by vitamin C applied on to the skin.
These results confirm the hypothesis of the underlying role of vitamin C deficiency in the determinism of Bateman purpura.
Bateman 紫癜的特征是弥漫性老年性皮肤萎缩、老年性紫癜和自发性星状假瘢。随着年龄的增长，皮肤的变化与老年人真皮中抗坏血酸水平降低有关。
本研究假设老年性紫癜可能与真皮维生素 C 缺乏有关，并可通过局部应用这种维生素来纠正。
对 18 例年龄大于 60 岁的 Bateman 紫癜患者进行了 12 周的半体（前臂或腿）、随机、双盲对照研究。每次就诊时均进行临床评估和生物测量。临床检查和专家评分显示，与对照侧相比，维生素 C 治疗侧的出血面积减少，真皮厚度增加，临床改善显著。
每天两次应用 5%的局部维生素 C 可明显改善皮肤症状，并可改善皮肤弹性和厚度。Bateman 紫癜是光老化的一个典型标志，其病因尚未明确，可通过皮肤涂抹维生素 C 得到改善。
这些结果证实了维生素 C 缺乏在 Bateman 紫癜发病机制中起重要作用的假设。
