钛杂环戊二烯催化的 N-酰化氮丙啶的自由基开环反应。
Titanocene-Catalyzed Radical Opening of N-Acylated Aziridines.
机构信息
Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121, Bonn, Germany.
Mulliken Center for Theoretical Chemistry, Universität Bonn, Germany.
出版信息
Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12654-12657. doi: 10.1002/anie.201707673. Epub 2017 Sep 8.
Aziridines activated by N-acylation are opened to the higher substituted radical through electron transfer from titanocene(III) complexes in a novel catalytic reaction. This reaction is applicable in conjugate additions, reductions, and cyclizations and suited for the construction of quaternary carbon centers. The concerted mechanism of the ring opening is indicated by DFT calculations.
氮酰化激活的氮丙啶通过来自二茂钛(III)配合物的电子转移，在新型催化反应中打开至高取代的自由基。该反应适用于共轭加成、还原和环化，适合构建季碳原子中心。DFT 计算表明，开环反应的协同机制。
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