Service de Psychiatrie, CHU de Caen, Caen, France.
Normandie Univ, UNICAEN, UFR de médecine (Medical School), Caen, France.
Bipolar Disord. 2017 Sep;19(6):496-504. doi: 10.1111/bdi.12526. Epub 2017 Aug 23.
The question of whether there is a continuum or a dichotomy among patients with schizophrenia (SZ) and bipolar disorders (BD) has not been clearly resolved and remains a challenge. Thus, the identification of specific biomarkers of these disorders might be helpful. The present study investigated the volume of the corpus callosum (CC) and functional lateralization for language as potential biomarkers and their relationships in SZ and BD.
The study included 20 patients with SZ, 20 patients with BD and 40 healthy controls (HC). A functional lateralization index (FLI) was computed for each participant within the language comprehension network. For each participant, the volume of the total CC and those of three subregions were extracted. These variables and their anatomo-functional relationships were investigated.
In comparison to HC, SZ patients presented a decreased leftward lateralization for language, whereas this was not found in BD patients. However, as compared to SZ patients and HC, BD patients showed a reduction in CC volume associated with a lower leftward lateralization for language.
Our study revealed that SZ patients displayed a reduction of the leftward functional lateralization for language; however, no reduction of CC volume was observed, whereas BD patients presented a decreased volume of the CC associated with a lower leftward asymmetry for language. The results of our study detected distinct anomalies in both SZ and BD that may be considered as specific biomarkers of these disorders related to neurodevelopmental models.
精神分裂症（SZ）和双相情感障碍（BD）患者之间是否存在连续体或二分法的问题尚未得到明确解决，仍然是一个挑战。因此，识别这些疾病的特定生物标志物可能会有所帮助。本研究调查了胼胝体（CC）体积和语言功能侧化作为潜在生物标志物及其在 SZ 和 BD 中的关系。
该研究纳入了 20 名 SZ 患者、20 名 BD 患者和 40 名健康对照者（HC）。为每位参与者计算了语言理解网络内的功能侧化指数（FLI）。为每位参与者提取了总 CC 及其三个亚区的体积。研究了这些变量及其解剖功能关系。
与 HC 相比，SZ 患者的语言左向侧化减少，而 BD 患者则没有。然而，与 SZ 患者和 HC 相比，BD 患者的 CC 体积减少与语言左向侧化降低有关。
我们的研究表明，SZ 患者表现出语言左向功能侧化减少；然而，CC 体积没有减少，而 BD 患者的 CC 体积减少与语言左向不对称性降低有关。我们的研究结果检测到 SZ 和 BD 中存在明显的异常，这些异常可能被视为与神经发育模型相关的这些疾病的特定生物标志物。
