Moneib Hoda A, Youssef Sahar S, Aly Dalia G, Rizk Mohamed A, Abdelhakeem Yomna I
Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt.
Department of Dermatology and Venereology, National Research Centre, Giza, Egypt.
J Cosmet Dermatol. 2018 Jun;17(3):495-501. doi: 10.1111/jocd.12401. Epub 2017 Aug 19.
Chronic venous leg ulcers drastically reduce the quality of life of affected patients. There is heightened interest in autologous platelet-rich plasma (PRP) as one of the promising therapies for leg ulcers.
Our aim was to compare the clinical efficacy of PRP in the management of chronic venous leg ulcers vs conventional treatment.
PATIENTS/METHODS: In total, 40 patients with chronic venous leg ulcers were included in the study. Twenty patients were treated with autologous PRP weekly for 6 weeks (Group A), and 20 patients were treated with conventional treatment (compression and dressing) for 6 weeks (Group B). Treatment results were calculated by percentage of improvement in area of the ulcer.
Compared to conventional therapy, a highly significant improvement in the ulcer size was observed post-PRP therapy (P-value = .0001). The mean change in the area of the ulcer post-PRP and conventional therapy was 4.92 ± 11.94 cm and 0.13 ± 0.27 cm, respectively, while the mean percentage improvement in the area of the ulcer post-PRP and conventional therapy was 67.6% ± 36.6% and 13.67% ± 28.06%, respectively. Subjective improvement in pain associated with the ulcer was noted by all patients.
Platelet-rich plasma is a safe nonsurgical procedure for treating chronic venous leg ulcers. Additional studies with larger sample size and longer follow-up periods are required to confirm or refute our findings.
下肢慢性静脉性溃疡严重降低了患者的生活质量。富血小板血浆（PRP）作为一种有前景的下肢溃疡治疗方法，受到了更多关注。
我们的目的是比较PRP治疗下肢慢性静脉性溃疡与传统治疗的临床疗效。
患者/方法：本研究共纳入40例下肢慢性静脉性溃疡患者。20例患者每周接受一次自体PRP治疗，共6周（A组），20例患者接受传统治疗（加压包扎）6周（B组）。治疗结果通过溃疡面积改善百分比计算。
与传统治疗相比，PRP治疗后溃疡大小有极显著改善（P值 = 0.0001）。PRP治疗和传统治疗后溃疡面积的平均变化分别为4.92±11.94平方厘米和0.13±0.27平方厘米，而PRP治疗和传统治疗后溃疡面积的平均改善百分比分别为67.6%±36.6%和13.67%±28.06%。所有患者均表示与溃疡相关的疼痛有主观改善。
富血小板血浆是治疗下肢慢性静脉性溃疡的一种安全的非手术方法。需要更多样本量和更长随访期的研究来证实或反驳我们的发现。
