Department of Dermatology, Hospital Severo Ochoa, Madrid, Spain.
Department of Dermatology, Hospital Doce de Octubre, Madrid, Spain.
Int Wound J. 2017 Dec;14(6):1323-1326. doi: 10.1111/iwj.12806. Epub 2017 Aug 17.
The present study assesses the efficacy and safety of topical sevoflurane in chronic venous ulcers and its impact on analgesia and healing. This retrospective study included 30 patients older than 65 years with painful refractory chronic venous ulcers. Patients were treated with topical sevoflurane prior to the usual ulcer cleaning every 2 days for a period of 1 month. Treatment was initiated with a saline solution, followed by direct irrigation of 1 ml of liquid sevoflurane over the wound size, which was measured as cm . Sevoflurane had a fast, intense and long-lasting analgesic effect. Latency time ranged from 2 to 7 minutes (3·9 ± 1·5 minutes), and duration varied from 8 to 18 hours (12 ± 2·9). The mean ulcer size was 8·4 ± 9·7 cm . There was a progressive decrease in size in all patients, with a mean size of 4·2 ± 5·4 cm at the end of the study. There were no adverse systemic effects. Local adverse effects were mild and transient, including pruritus, erythema and heat. Topical sevoflurane is a new, efficient and safe therapeutic alternative in painful chronic venous ulcers, refractory to usual analgesic treatment. It can improve the ulcer-healing process that shortens the cicatrisation period.
本研究评估了局部七氟醚在慢性静脉性溃疡中的疗效和安全性及其对镇痛和愈合的影响。这是一项回顾性研究，纳入了 30 名年龄大于 65 岁、存在疼痛性难治性慢性静脉性溃疡的患者。患者在常规溃疡清洁前接受局部七氟醚治疗，每 2 天治疗 1 次，持续 1 个月。治疗开始时使用生理盐水，然后直接将 1ml 液体七氟醚冲洗至伤口大小（以 cm 计）。七氟醚具有起效快、作用强且持续时间长的镇痛效果。潜伏期为 2 至 7 分钟（3.9±1.5 分钟），作用持续时间为 8 至 18 小时（12±2.9 小时）。平均溃疡大小为 8.4±9.7cm。所有患者的溃疡大小均逐渐缩小，研究结束时平均大小为 4.2±5.4cm。未发生全身不良反应。局部不良反应轻微且短暂，包括瘙痒、红斑和发热。局部七氟醚是一种新的、有效且安全的治疗选择，适用于对常规镇痛治疗无效的疼痛性慢性静脉性溃疡。它可以改善溃疡愈合过程，缩短愈合期。
