急性和慢性给予吗啡后大鼠胎盘中的前列腺素

Prostaglandins in rat placenta following acute and chronic administration of morphine.

作者信息

Scoto G M, Spadaro C, Spampinato S, Nossan N, Arrigo-Reina R, Ferri S

出版信息

Arch Toxicol Suppl. 1979(2):375-80. doi: 10.1007/978-3-642-67265-1_41.

Abstract

The objective of the present study was to obtain information on prostaglandin (PG) biosynthesis in placenta following narcotic administration. PG biosynthetic capacity was determined in whole rat placenta homogenates in the presence of Na arachidonate, by evaluating net production of PGs assayed against PGE1 on rat stomach strips. An enhanced prostaglandin-like activity is shown in homogenates of placenta from rats treated subcutaneously with 10 mg/kg of morphine. This increase was prevented by naloxone pre-treatment. Continual morphine administration during gestation, results in a normalization of placental biosynthetic capacity thus suggesting the development of a tolerance to the narcotic effect.

摘要

本研究的目的是获取关于麻醉剂给药后胎盘前列腺素（PG）生物合成的信息。通过评估在花生四烯酸钠存在下，大鼠全胎盘匀浆中PG的生物合成能力，以大鼠胃条上PGE1为对照测定PG的净产量。皮下注射10mg/kg吗啡的大鼠胎盘匀浆显示出增强的类前列腺素活性。这种增加可被纳洛酮预处理所阻止。孕期持续给予吗啡会导致胎盘生物合成能力正常化，从而提示对麻醉作用产生了耐受性。