Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, People's Republic of China.
Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, People's Republic of China.
Radiat Oncol. 2017 Aug 23;12(1):141. doi: 10.1186/s13014-017-0874-0.
To investigate the clinical value of preoperative and postoperative radiotherapy (RT) in patients with rectal signet-ring cell carcinoma (SRCC).
Using the Surveillance, Epidemiology, and End Results program patients with stage II-III rectal SRCC were retrospectively included between 1988 and 2012. Univariate and multivariate Cox regression analyses were performed to analyze the effect of preoperative and postoperative RT on cause-specific survival (CSS).
A total of 292 patients were included: 138 patients received preoperative RT, 101 patients received postoperative RT, and 53 patients underwent surgery alone. Overall, 5- and 10-year CSS was 43.8 and 37.6%, respectively. Preliminary survival analysis demonstrated that preoperative RT improved CSS versus surgery alone, especially in patients with stage III disease. Multivariate analysis demonstrated that preoperative RT was independent predictors for CSS in stage III rectal SRCC. CSS in preoperative and postoperative RT groups was comparable.
Preoperative RT significantly improved survival outcomes in patients with stage III rectal SRCC.
研究直肠印戒细胞癌（SRCC）患者术前和术后放疗（RT）的临床价值。
使用监测、流行病学和最终结果（SEER）计划，回顾性纳入 1988 年至 2012 年间 II-III 期直肠 SRCC 患者。采用单因素和多因素 Cox 回归分析评估术前和术后 RT 对特异性生存（CSS）的影响。
共纳入 292 例患者：138 例接受术前 RT，101 例接受术后 RT，53 例仅接受手术治疗。总体而言，5 年和 10 年 CSS 分别为 43.8%和 37.6%。初步生存分析表明，与单独手术相比，术前 RT 改善了 CSS，尤其是在 III 期疾病患者中。多因素分析表明，术前 RT 是 III 期直肠 SRCC CSS 的独立预测因素。术前和术后 RT 组的 CSS 无显著差异。
术前 RT 显著改善了 III 期直肠 SRCC 患者的生存结局。
