Sullivan Olivia, Gong Zongyi, Klanian Kelly, Patel Tushita, Williams Mark B
University of Virginia Department of Physics, Charlottesville, Virginia, USA.
University of Virginia Department of Biomedical Engineering Charlottesville, Virginia, USA.
Breast Imaging (2012). 2012 Jul;7361:300-307. doi: 10.1007/978-3-642-31271-7_39.
This study's objective is to compare image quality in 3-D molecular breast imaging tomosynthesis (MBIT) with that in planar molecular breast imaging (MBI) over a range of breast radioactivity concentrations. Using gelatin and point source phantoms lesion contrast, lesion signal-to-noise ratio (SNR) and spatial resolution were compared for a range of lesion sizes and depths. For both MBI and MBIT, lesion contrast is essentially constant with changing activity while SNR decreases by a factor of 1.5 - 2 between 100% and 25% activity levels. For nearly all lesion sizes and locations contrast and SNR are significantly higher for MBIT than MBI, potentially permitting greater reductions in injected dose. Spatial resolution in MBI is dependent on lesion depth but independent of lesion location with MBIT. Reconstructed MBIT spatial resolution is substantially better than that in the projection images, suggesting future use of higher sensitivity collimators for even further reductions in injected activity.
本研究的目的是在一系列乳腺放射性浓度范围内，比较三维分子乳腺成像断层合成（MBIT）与平面分子乳腺成像（MBI）的图像质量。使用明胶和点源体模，针对一系列病变大小和深度，比较了病变对比度、病变信噪比（SNR）和空间分辨率。对于MBI和MBIT，随着活性变化，病变对比度基本保持恒定，而在100%至25%活性水平之间，SNR降低了1.5至2倍。对于几乎所有病变大小和位置，MBIT的对比度和SNR均显著高于MBI，这可能允许更大程度地降低注射剂量。MBI中的空间分辨率取决于病变深度，但在MBIT中与病变位置无关。重建后的MBIT空间分辨率明显优于投影图像，这表明未来使用更高灵敏度的准直器可进一步降低注射活性。
