[AlCl(BnMe-tacn)]——一种通过氯/氟交换进行放射性氟化的新型金属螯合物支架。
[AlCl(BnMe-tacn)] - a new metal chelate scaffold for radiofluorination by Cl/F exchange.
作者信息
Levason William, Luthra Sajinder K, McRobbie Graeme, Monzittu Francesco M, Reid Gillian
机构信息
Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK.
出版信息
Dalton Trans. 2017 Oct 31;46(42):14519-14522. doi: 10.1039/c7dt02122d.
Radiofluorination of a 2.63 μM solution (pH 4, NaOAc buffer) of [AlCl(BnMe-tacn)] via treatment with 2.99 mol. equiv. of [F]KF doped with cyclotron-produced [F]F target water, with heating to 80-100 °C for 1 h, gives up to 24% F incorporation. SPE purification of the [AlFF(BnMe-tacn)] radio-product gives >99% RCP, with excellent stability (>99% RCP after 3 h).
通过用2.99摩尔当量的掺杂有回旋加速器产生的[F]F靶水的[F]KF处理2.63μM溶液（pH 4，NaOAc缓冲液）中的[AlCl(BnMe-tacn)]，加热至80-100°C 1小时，可实现高达24%的氟掺入。对[AlFF(BnMe-tacn)]放射性产物进行固相萃取纯化，放射化学纯度>99%，稳定性极佳（3小时后放射化学纯度>99%）。
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