通过氙增强CT测量的脑肿瘤局部脑血流量

rCBF in brain tumours as measured by xenon enhanced CT.

作者信息

Nakamura O, Segawa H, Tanaka H, Yoshimasu N, Nagai M, Takakura K

出版信息

Neurol Res. 1987 Mar;9(1):24-9. doi: 10.1080/01616412.1987.11739767.

DOI:10.1080/01616412.1987.11739767

Abstract

Heretofore, the rCBF of brain tumours has been measured by the 133Xe clearance method, but the resolving power of this method is limited and flow values measured by this method correlate poorly with the anatomical structure. On the other hand, our xenon-enhanced method has several advantages over the conventional isotope method and enables us to evaluate rCBF with a resolving power of 4 mm. With this method, we evaluated rCBF in 15 brain tumour cases and obtained the following results: Mean rCBF value of the tumour is a little lower than that of grey matter and higher than that of white matter with oedematous change. The xenon-enhanced method enables us to distinguish the demarcation between the tumour area and the surrounding oedematous area and offers useful information for determining the extent of resection in surgery. Mean lambda value of the tumour which is not obtainable in vivo by radionuclide scanning, was 1.02 +/- 0.06 for gliomas and 0.72 +/- 0.09 for metastatic tumours.

摘要

在此之前，脑肿瘤的局部脑血流量（rCBF）是通过133氙清除法测量的，但该方法的分辨率有限，且用此方法测得的血流值与解剖结构的相关性较差。另一方面，我们的氙增强法相对于传统同位素法具有若干优势，能够让我们以4毫米的分辨率评估rCBF。通过该方法，我们对15例脑肿瘤病例的rCBF进行了评估，得出以下结果：肿瘤的平均rCBF值略低于灰质，高于有水肿变化的白质。氙增强法能够让我们区分肿瘤区域与周围水肿区域之间的界限，并为确定手术切除范围提供有用信息。肿瘤的平均λ值在体内通过放射性核素扫描无法获得，胶质瘤的平均λ值为1.02±0.06，转移性肿瘤的平均λ值为0.72±0.09。