Iacono R P, Linford J, Sandyk R
Neurosurgery. 1987 Mar;20(3):496-500. doi: 10.1227/00006123-198703000-00027.
Phantom pain may occur in up to 85% of patients after limb amputation. Although the pathophysiology of postamputation phantom pain is not well understood, it seems to be produced by a complex multifactorial interaction between the peripheral, sympathetic, and central nervous systems. The theoretical aspects of this are reviewed. Management of phantom limb pain may be both medical and surgical. Among the pharmacological agents proved effective against phantom pain are beta-blockers, tricyclic antidepressants, and anticonvulsants. Surgical management includes peripheral nerve stimulation, thermocontrolled coagulation of the spinal cord, spinal cord stimulation, transcutaneous nerve stimulation, and stereotactic deep brain stimulation.
高达85%的截肢患者可能会出现幻肢痛。虽然截肢后幻肢痛的病理生理学尚未完全明确，但它似乎是由外周、交感和中枢神经系统之间复杂的多因素相互作用产生的。本文对其理论方面进行了综述。幻肢痛的治疗可采用药物治疗和手术治疗。已证实对幻肢痛有效的药物包括β受体阻滞剂、三环类抗抑郁药和抗惊厥药。手术治疗包括外周神经刺激、脊髓温控凝固、脊髓刺激、经皮神经刺激和立体定向深部脑刺激。
