黑质纹状体损伤增强纹状体3H-阿扑吗啡和3H-螺哌啶醇结合。
Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding.
作者信息
Creese I, Snyder S H
出版信息
Eur J Pharmacol. 1979 Jun 15;56(3):277-81. doi: 10.1016/0014-2999(79)90184-5.
PMID:38973
Abstract
Following unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.
摘要
在大鼠单侧6-羟基多巴胺黑质纹状体损伤后，纹状体内3H-阿扑吗啡和3H-螺哌啶醇的结合均增加。在损伤不完全的大鼠或损伤后的早期时间点，结合与对照水平无显著差异。
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