地西泮可恢复杏仁核点燃大鼠海马突触膜上增加的[3H]谷氨酸结合。

Diazepam restores the increased [3H]glutamate binding to hippocampal synaptic membranes in the amygdaloid-kindled rat.

作者信息

Oka J, Yamada M, Goto M, Fukuda H

出版信息

Neurosci Res. 1987 Feb;4(3):185-94. doi: 10.1016/0168-0102(87)90011-3.

Abstract

[3H]Glutamic acid binding to hippocampi was increased after amygdaloid kindling in rats, and diazepam inhibited this increased binding, without any effect on the enhanced binding by CaCl2 or the binding in control rats. By inducing kindling in the same way as that used in the binding experiment, the inhibiting effects of diazepam on kindled seizures, the afterdischarge and the development of kindling were observed.

摘要

大鼠杏仁核点燃后，[3H]谷氨酸与海马体的结合增加，地西泮可抑制这种结合增加，对氯化钙增强的结合或对照大鼠的结合无任何影响。通过与结合实验相同的方式诱导点燃，观察到地西泮对点燃性癫痫发作、后放电和点燃发展的抑制作用。