Kostowski W, Malatyńska E, Płaźnik A, Dyr W, Danysz W
Pol J Pharmacol Pharm. 1986 Sep-Dec;38(5-6):471-81.
Alprazolam, a new benzodiazepine from triazolobenzodiazepine group, produced anxiolytic action in the conflict test with potency similar to that of diazepam. The myorelaxant activity of the drug was relatively weak. Unlike desipramine, alprazolam failed to reduce the immobility of rats in the forced swim test and was unable to prevent clonidine-induced hypothermia. Alprazolam, unlike desipramine, failed also to potentiate behavioral effect of noradrenaline injected into the hippocampus. Alprazolam after acute but not chronic administration antagonized the synchronizing effect of clonidine on EEG pattern. On the other hand, alprazolam similarly to tricyclic antidepressants, prevented the suppression of dominance behavior by clonidine in rats competing for food. The results indicate that alprazolam acts only weakly upon noradrenergic mechanisms related to depression and to antidepressant action of drugs.
阿普唑仑是三唑并苯二氮䓬类的一种新型苯二氮䓬，在冲突试验中产生抗焦虑作用，效力与地西泮相似。该药物的肌松活性相对较弱。与地昔帕明不同，阿普唑仑在强迫游泳试验中未能降低大鼠的不动时间，也无法预防可乐定引起的体温过低。与地昔帕明不同，阿普唑仑也未能增强注入海马体的去甲肾上腺素的行为效应。急性而非慢性给药后的阿普唑仑拮抗了可乐定对脑电图模式的同步作用。另一方面，阿普唑仑与三环类抗抑郁药类似，可防止可乐定对争夺食物的大鼠的优势行为产生抑制作用。结果表明，阿普唑仑对与抑郁及药物抗抑郁作用相关的去甲肾上腺素能机制的作用较弱。
