自身双链DNA在系统性红斑狼疮发病机制中的作用
Self-dsDNA in the pathogenesis of systemic lupus erythematosus.
作者信息
Bai Y, Tong Y, Liu Y, Hu H
机构信息
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
Clin Exp Immunol. 2018 Jan;191(1):1-10. doi: 10.1111/cei.13041. Epub 2017 Sep 15.
Abstract
Systemic lupus erythematosus (SLE) is a systemic and poly-aetiological autoimmune disease characterized by the production of antibodies to autologous double-stranded DNA (dsDNA) which serve as diagnostic and prognostic markers. The defective clearance of apoptotic material, together with neutrophil extracellular traps (NETs), provides abundant chromatin or self-dsDNA to trigger the production of anti-dsDNA antibodies, although the mechanisms remain to be elucidated. In SLE patients, the immune complex (IC) of dsDNA and its autoantibodies trigger the robust type I interferon (IFN-I) production through intracellular DNA sensors, which drives the adaptive immune system to break down self-tolerance. In this review, we will discuss the potential resources of self-dsDNA, the mechanisms of self-dsDNA-mediated inflammation through various DNA sensors and its functions in SLE pathogenesis.
摘要
系统性红斑狼疮（SLE）是一种全身性、多病因的自身免疫性疾病，其特征是产生针对自身双链DNA（dsDNA）的抗体，这些抗体可作为诊断和预后标志物。凋亡物质清除缺陷以及中性粒细胞胞外诱捕网（NETs）提供了大量染色质或自身dsDNA，从而触发抗dsDNA抗体的产生，尽管其机制仍有待阐明。在SLE患者中，dsDNA及其自身抗体的免疫复合物（IC）通过细胞内DNA传感器触发强大的I型干扰素（IFN-I）产生，这促使适应性免疫系统破坏自身耐受性。在本综述中，我们将讨论自身dsDNA的潜在来源、通过各种DNA传感器介导自身dsDNA炎症的机制及其在SLE发病机制中的作用。
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