一种具有伸展构象的部分刚性丁酰苯类似物。
A partially rigid butyrophenone analog with extended conformation.
作者信息
Chan C C, Farmer P S
出版信息
Pharmazie. 1986 Dec;41(12):835-6.
PMID:2883672
Abstract
The synthesis and in vitro dopamine D2 receptor binding of a conformationally restricted analog of 4-piperidinobutyrophenone is described. 2-(2-Piperidinoethyl)-1-tetralone displaces [3H]spiperone from the rat striatal dopamine receptor with an IC50 of 1.2 X 10(-4)mol/l.
摘要
描述了一种4-哌啶丁酰苯构象受限类似物的合成及其体外多巴胺D2受体结合情况。2-(2-哌啶基乙基)-1-四氢萘酮以1.2×10(-4)mol/l的IC50从大鼠纹状体多巴胺受体上取代[3H]司哌罗。
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