黄体期使用雌二醇及其对采用GnRH拮抗剂的体外受精周期妊娠率的影响：一项系统评价
Estradiol use in the luteal phase and its effects on pregnancy rates in IVF cycles with GnRH antagonist: a systematic review.
作者信息
Pinheiro Lanna Marla Andrade, Cândido Priscilla da Silva, Moreto Tássia Camila, Almeida Wanessa Gonzaga Di, Castro Eduardo Camelo de
机构信息
Infertility Clinic, Faculty of Medicine, Catholic University of Goiás, Goiânia, GO, Brazil.
出版信息
JBRA Assist Reprod. 2017 Sep 1;21(3):247-250. doi: 10.5935/1518-0557.20170046.
Abstract
For all the steps of in vitro fertilization to occur successfully, factors such as the quality of retrieved oocytes and endometrial receptivity to the embryo must be ensured. Current studies have shown that endometrial receptivity can be optimized using dedicated exogenous progesterone for luteal phase support in assisted reproduction cycles. But it has not yet been established the benefits of additional use of estradiol in this support. Analyzing pituitary suppression protocols that employ GnRH antagonists, this review will address literature publications between the years 2000-2016, shedding light on this issue to answer questions about the benefits of supplementation.
摘要
为使体外受精的所有步骤都能成功进行，必须确保诸如获取的卵母细胞质量和子宫内膜对胚胎的接受性等因素。目前的研究表明，在辅助生殖周期中使用专用的外源性孕酮进行黄体期支持，可以优化子宫内膜的接受性。但在这种支持中额外使用雌二醇的益处尚未得到证实。通过分析采用GnRH拮抗剂的垂体抑制方案，本综述将探讨2000年至2016年间的文献出版物，阐明这一问题，以回答关于补充剂益处的疑问。
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