Schwab Mira, Herold Dominik, Thiele Christina M
Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, Alarich-Weiss-Strasse 4, 64287, Darmstadt, Germany.
Chemistry. 2017 Oct 17;23(58):14576-14584. doi: 10.1002/chem.201702884. Epub 2017 Sep 18.
Lyotropic liquid crystalline phases of poly-β-phenethylaspartates are presented as new helically chiral enantiodifferentiating alignment media with thermoresponsive properties. In addition to displaying the highest enantiodifferentiation observed for homopolypeptides, the alignment media undergo a temperature induced helix reversal without perturbing the nematic phase. This offers the opportunity to measure residual dipolar couplings (RDCs) in high and low temperature helix conformation (P- and M-helix) in one polymer. Thus different mean orientations of a chiral analyte can be determined within the same sample. Furthermore, we investigated whether the resulting media are diastereomeric and whether we are able to obtain information about the alignment process.
聚-β-苯乙天冬氨酸的溶致液晶相作为具有热响应特性的新型螺旋手性对映体分化取向介质被呈现出来。除了展现出在均聚多肽中观察到的最高对映体分化外，该取向介质还会发生温度诱导的螺旋反转，而不会干扰向列相。这为在一种聚合物中测量高温和低温螺旋构象（P-螺旋和M-螺旋）下的剩余偶极耦合（RDC）提供了机会。因此，可以在同一样品中确定手性分析物的不同平均取向。此外，我们研究了所得介质是否为非对映异构体，以及我们是否能够获得有关取向过程的信息。
