Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.
Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California.
Retina. 2018 Aug;38(8):1518-1525. doi: 10.1097/IAE.0000000000001810.
To describe the sequential evolution of outer retinal tubulations (ORTs) in patients diagnosed with choroidal neovascularization and/or retinal pigment epithelium atrophy.
Retrospective evaluation of spectral domain optical coherence tomography of a consecutive cohort of patients with various retinal conditions.
We reviewed the clinical findings of 238 eyes of 119 consecutive patients (54 men and 65 women) with a mean age of 76.2 ± 14.2 years (range: 57-90) and a mean follow-up of 3 ± 1.6 years (range 1-7). Over the follow-up period, ORTs were diagnosed in 67 of 238 eyes (28.1%), 9 of which were imaged with sequential, eye-tracked spectral domain optical coherence tomography dating from the beginning of ORT formation. The presence of geographic atrophy and subretinal hyperreflective material at baseline were found to be risk factors for ORT development (P < 0.001 and P < 0.001, respectively). Outer retinal tubulations were divided into forming versus formed morphologies. The latter was comprised open and closed ORTs of which the open subtype was the most common. The formation of ORTs was significantly associated with microcystic macular lesions in the inner nuclear layer and the downward displacement of the outer plexiform layer, referred to as the outer plexiform layer subsidence sign (P < 0.001).
Outer retinal tubulation is a frequent optical coherence tomography finding in eyes with choroidal neovascularization and geographic atrophy. Open ORTs with progressive scrolled edges and shortened diameter were significantly associated with microcystic macular lesions in the inner nuclear layer and the outer plexiform layer subsidence sign.
描述诊断为脉络膜新生血管和/或视网膜色素上皮萎缩患者的外视网膜管腔（ORTs）的顺序演变。
对一系列具有各种视网膜疾病的患者的光谱域光相干断层扫描进行回顾性评估。
我们回顾了 119 例连续患者的 238 只眼的临床发现（54 名男性和 65 名女性），平均年龄为 76.2 ± 14.2 岁（范围：57-90），平均随访时间为 3 ± 1.6 年（范围 1-7）。在随访期间，238 只眼中有 67 只（28.1%）被诊断为 ORTs，其中 9 只通过从 ORT 形成开始的连续眼追踪光谱域光相干断层扫描进行成像。基线时存在地理萎缩和视网膜下高反射物质被发现是 ORT 发展的危险因素（分别为 P < 0.001 和 P < 0.001）。外视网膜管腔分为形成和已形成形态。后者由开放和闭合的 ORTs 组成，其中开放亚型最为常见。ORTs 的形成与内核层中的微囊样黄斑病变和外丛状层的向下移位，即外丛状层下沉征显著相关（P < 0.001）。
在外眼有脉络膜新生血管和地理萎缩的患者中，外视网膜管腔是一种常见的光学相干断层扫描发现。具有进行性卷曲边缘和缩短直径的开放 ORTs 与内核层中的微囊样黄斑病变和外丛状层下沉征显著相关。
