Sauer-Budge Alexis F, Brookfield Samuel J, Janzen Ronald, McGray Sarah, Boardman Anna, Wirz Holger, Pollock Nira R
Center for Manufacturing Innovation, Fraunhofer USA, Brookline, Massachusetts, United States of America.
Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America.
PLoS One. 2017 Aug 24;12(8):e0183625. doi: 10.1371/journal.pone.0183625. eCollection 2017.
The increased world-wide availability of point-of-care (POC) tests utilizing fingerstick blood has led to testing scenarios in which multiple separate fingersticks are performed during a single patient encounter, generating cumulative discomfort and reducing testing efficiency. We have developed a device capable of a) collection of up to 100 μL of fingerstick blood from a single fingerstick by capillary action, and b) dispensing this blood in variable increments set by the user. We tested the prototype device both in a controlled laboratory setting and in a fingerstick study involving naive device users, and found it to have accuracy and precision similar to a conventional pipettor. The users also found the device to be easy to use, and recommended minor ergonomic improvements. Our device would allow performance of multiple POC tests from a single fingerstick blood sample, thus providing a novel functionality that may be of use in many testing settings worldwide.
全球范围内利用指尖采血的即时检验（POC）检测方法日益普及，这导致在单次患者诊疗过程中需要进行多次单独的指尖采血检测，从而增加了累积不适感并降低了检测效率。我们开发了一种装置，该装置能够：a）通过毛细作用从单次指尖采血中采集多达100微升的指尖血；b）按照用户设定的可变增量分配这些血液。我们在受控实验室环境以及涉及初次使用该装置的用户的指尖采血研究中对该原型装置进行了测试，发现其准确度和精密度与传统移液器相似。用户还发现该装置易于使用，并建议对人体工程学进行一些小的改进。我们的装置能够从单个指尖血样本进行多次即时检验，从而提供了一种新功能，这可能在全球许多检测环境中都有用处。
