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撤回:miR-367 对 DOC-2/DAB2 相互作用蛋白的调控促进骨肉瘤细胞的增殖、迁移和侵袭。

RETRACTED: miR-367 regulation of DOC-2/DAB2 interactive protein promotes proliferation, migration and invasion of osteosarcoma cells.

机构信息

Orthopedics Department, Huai'an, Jiangsu Province 223300, China.

Anesthesiology Department, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu Province 223300, China.

出版信息

Biomed Pharmacother. 2017 Nov;95:120-128. doi: 10.1016/j.biopha.2017.07.158. Epub 2017 Sep 12.

DOI:10.1016/j.biopha.2017.07.158
PMID:28837878
Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors, who have informed the Editor-in-Chief that miR-367 overexpression did not significantly reduce the DAB2IP level in MG-63 cells as shown in Figures 4C and 4D of the published article. Furthermore, the effects of miR-367 overexpression and DAB2IP knockdown on the proliferation and metastasis of MG-63 cells in Figure 2 and Figure 6 are also no longer repeatable. Subsequent analysis showed that the MG-63 cells used in this study were contaminated with HeLa cells, identified by short tandem repeat analysis. The authors believe cell contamination may be the main reason why the reported results are not reproducible. The authors no longer have confidence in the reliability of the results and would like to apologize for any inconvenience caused. The Editor-in-Chief agreed to retract the article.

摘要

本文已被撤回

请参阅爱思唯尔撤稿政策(http://www.elsevier.com/locate/withdrawalpolicy)。应作者要求,本文已被撤回,作者告知主编,如图 4C 和 4D 所示,miR-367 的过表达并未显著降低已发表文章中 MG-63 细胞中的 DAB2IP 水平。此外,miR-367 过表达和 DAB2IP 敲低对图 2 和图 6 中 MG-63 细胞增殖和转移的影响也不再具有可重复性。后续分析表明,本研究中使用的 MG-63 细胞被 HeLa 细胞污染,通过短串联重复分析鉴定。作者认为细胞污染可能是导致报道结果不可重复的主要原因。作者对结果的可靠性不再有信心,并对由此造成的任何不便表示歉意。主编同意撤回该文章。

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