生长抑素类似物对肢端肥大症中异常生长激素反应的影响。

The effect of minisomatostatin on anomalous growth hormone responses in acromegaly.

作者信息

Pieters G F, Smals A E, Smals A G, von Gennep J A, Kloppenborg P W

出版信息

Acta Endocrinol (Copenh). 1987 Apr;114(4):537-42. doi: 10.1530/acta.0.1140537.

DOI:10.1530/acta.0.1140537

Abstract

Twelve patients with active acromegaly were treated with the long-acting somatostatin analogue SMS 201-995 at a dose of 50 micrograms sc twice daily in the first 2 weeks of treatment and 100 micrograms twice daily thereafter. Four hours after the first injection of SMS, GH levels became normal in 8 of the 12 patients. The GH response after hpGRF administration was strongly suppressed by SMS. Paradoxical GH responses to TRH disappeared in 6 out of 7 patients during SMS. Paradoxical GH responses to LHR, however, persisted in 4 out of 4 patients. Paradoxical responses of GH after glucose loading disappeared in 2 out of 2 patients. We conclude that SMS normalizes most anomalous growth hormone kinetics in acromegaly. This drug offers a new tool in the treatment of this disease.

摘要

12例活动期肢端肥大症患者接受长效生长抑素类似物SMS 201-995治疗，治疗的前2周剂量为50微克皮下注射，每日2次，之后为100微克每日2次。首次注射SMS 4小时后，12例患者中有8例生长激素（GH）水平恢复正常。SMS强烈抑制了hpGRF给药后的GH反应。7例患者中有6例在使用SMS期间对促甲状腺激素释放激素（TRH）的反常GH反应消失。然而，4例患者中有4例对促黄体生成素释放激素（LHR）的反常GH反应持续存在。2例患者在葡萄糖负荷后GH的反常反应消失。我们得出结论，SMS可使肢端肥大症中大多数异常的生长激素动力学恢复正常。这种药物为该疾病的治疗提供了一种新工具。