Smith R C, Baumgartner R, Ravichandran G K, Largen J, Calderon M, Burd A, Mauldin M
Acta Psychiatr Scand. 1987 Jan;75(1):11-9. doi: 10.1111/j.1600-0447.1987.tb02745.x.
The relationship between clinical response to neuroleptics and brain morphology as revealed by CT scans was evaluated in a sample of 39 patients with schizophrenia and schizoaffective psychosis. Four measures of brain morphology previously shown to differ between schizophrenics and patients with headaches - white matter density, asymmetry in brain white matter density, sulcal width and global cortical atrophy - did not correlate with clinical improvement after 3 weeks treatment with constant doses of neuroleptics. These brain morphology measures also did not correlate with baseline psychopathology scores. The same results were found with scales or subscales reflecting primarily positive symptoms of schizophrenia as well as those reflecting primarily social withdrawal.
通过对39例精神分裂症和分裂情感性精神病患者的样本进行研究，评估了CT扫描所显示的抗精神病药物临床反应与脑形态之间的关系。先前已表明，精神分裂症患者与头痛患者在脑形态的四项指标上存在差异，即白质密度、脑白质密度不对称性、脑沟宽度和全脑皮质萎缩，但在给予固定剂量的抗精神病药物治疗3周后，这些指标与临床改善情况并无相关性。这些脑形态指标也与基线精神病理学评分无关。无论是反映精神分裂症主要阳性症状的量表或分量表，还是主要反映社交退缩的量表或分量表，均得到相同结果。
