Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, South west, Rochester, MN 55905, USA; Division of Gastroenterology, Thai Red Cross Society, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Rama IV Road, Bangkok, 10330, Thailand.
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, South west, Rochester, MN 55905, USA; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.
Gastroenterol Clin North Am. 2017 Sep;46(3):463-480. doi: 10.1016/j.gtc.2017.05.003. Epub 2017 Jul 19.
Crohn's disease (CD) is a chronic condition that can result in significant morbidity and disability. By studying the association between demographics and initial clinical features and subsequent natural history, one may be able to stratify patients by their risks of clinical relapse, hospitalization, and surgery. Understanding the potential environmental risk factors and natural history of CD in a given patient guides the physician when counseling the patient and selecting a treatment strategy. In this review, updated data regarding the incidence and prevalence of CD, important environmental risk factors, natural history of the disease, and important prognostic factors are discussed.
克罗恩病（CD）是一种慢性疾病，可导致显著的发病率和残疾。通过研究人口统计学和初始临床特征与随后自然病程之间的关联，人们可以根据患者临床复发、住院和手术的风险对其进行分层。了解特定患者中 CD 的潜在环境风险因素和自然病程可指导医生为患者提供咨询和选择治疗策略。在这篇综述中，讨论了 CD 的发病率和患病率、重要的环境风险因素、疾病的自然病程以及重要的预后因素的最新数据。
