Ferng Alice, Connell Alana, Nunez Martha, Johnson Kitsie, Braunhut Beth, Lick Scott, Desai Ankit, Kazui Toshinobu, Runyan Ray, Khalpey Zain
Division of Cardiothoracic Surgery, Department of Surgery, University of Arizona College of Medicine, Tucson, Arizona.
Department of Cell and Molecular Medicine, University of Arizona, Tucson, Arizona.
Ann Thorac Surg. 2017 Sep;104(3):e239-e241. doi: 10.1016/j.athoracsur.2017.03.044.
CorMatrix is an organic extracellular matrix (ECM) derived from porcine small intestine submucosa and is used for pericardial closure and cardiac tissue repair. During explantation of a HeartMate II (Thoratec Corp, Pleasanton, CA) left ventricular assist device (LVAD) because of infection, CorMatrix was used to repair the left ventricular apex and aorta. Three months later, a HeartWare HVAD (HeartWare International, Inc, Framingham, MA) was implanted for recurrent heart failure. Excised apical CorMatrix samples showed cardiac tissue remodeling with viable cardiomyoblasts similar to native myocardium. Excised CorMatrix from the aorta showed organization of collagen and elastin similar to native aortic tissue.
CorMatrix是一种源自猪小肠黏膜下层的有机细胞外基质（ECM），用于心包闭合和心脏组织修复。在因感染而取出HeartMate II（Thoratec公司，加利福尼亚州普莱森顿）左心室辅助装置（LVAD）期间，CorMatrix被用于修复左心室尖部和主动脉。三个月后，因复发性心力衰竭植入了HeartWare HVAD（HeartWare国际公司，马萨诸塞州弗雷明汉）。切除的尖部CorMatrix样本显示心脏组织重塑，有与天然心肌相似的存活心肌母细胞。从主动脉切除的CorMatrix显示出与天然主动脉组织相似的胶原蛋白和弹性蛋白组织。
