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低剂量阿司匹林治疗慢性硬膜下血肿患者的管理:一项国际实践调查

The Management of Patients with Chronic Subdural Hematoma Treated with Low-Dose Acetylsalicylic Acid: An International Survey of Practice.

作者信息

Soleman Jehuda, Kamenova Maria, Guzman Raphael, Mariani Luigi

机构信息

Department of Neurosurgery, University Hospital of Basel, Basel, Switzerland.

Department of Neurosurgery, University Hospital of Basel, Basel, Switzerland.

出版信息

World Neurosurg. 2017 Nov;107:778-788. doi: 10.1016/j.wneu.2017.08.065. Epub 2017 Aug 31.

Abstract

BACKGROUND

The aim of this international survey was to investigate the current management of patients undergoing surgery for chronic subdural hematoma (cSDH) treated with low-dose acetylsalicylic acid (ASA).

METHODS

We administered a survey via e-mail to neurosurgeons with questions relating to the surgical treatment of cSDH, emphasizing their practices with patients treated with low-dose ASA.

RESULTS

We received 157 responses, with a response rate of 22.4%. Almost 80% of the responders discontinue ASA treatment at least 5 days before surgery and 80.7% resume treatment after 5 days or more, and 27.6% discontinue treatment for at least 30 days. The main factor influencing ASA resumption time is the indication for ASA (54.5%), and postoperative imaging is concluded in 71.7%, Postoperative thrombosis prophylaxis is administered by 60% of the responders, and 50% apply it 24 hours after surgery. Almost 95% of the responders believe that better evidence is needed for the management of patients with cSDH treated with ASA. Guidelines for these patients exist in only 24.3% of the institutes.

CONCLUSIONS

Most neurosurgeons discontinue ASA treatment for at least 7 days in the perioperative period of surgical evacuation of cSDH, even though recent studies show that early ASA resumption might be safe. Thrombosis prophylaxis is administered by only 60%, even though patients with cSDH are at high risk of developing thromboembolic complications. Better evidence and guidelines are warranted because the incidence of patients with cSDH under the treatment of ASA is increasing.

摘要

背景

这项国际调查的目的是研究接受低剂量阿司匹林(ASA)治疗的慢性硬膜下血肿(cSDH)患者的当前管理情况。

方法

我们通过电子邮件向神经外科医生进行了一项调查,问题涉及cSDH的手术治疗,重点是他们对接受低剂量ASA治疗患者的治疗方法。

结果

我们收到了157份回复,回复率为22.4%。近80%的回复者在手术前至少5天停用ASA治疗,80.7%在5天或更长时间后恢复治疗,27.6%的人至少停药30天。影响ASA恢复时间的主要因素是使用ASA的指征(54.5%),71.7%的人进行了术后影像学检查,60%的回复者进行了术后血栓预防,50%在术后24小时应用。近95%的回复者认为,对于接受ASA治疗的cSDH患者的管理,需要更好的证据。只有24.3%的机构有针对这些患者的指南。

结论

大多数神经外科医生在cSDH手术清除的围手术期将ASA治疗至少停用7天,尽管最近的研究表明早期恢复使用ASA可能是安全的。尽管cSDH患者发生血栓栓塞并发症的风险很高,但只有60%的人进行了血栓预防。由于接受ASA治疗的cSDH患者的发病率在增加,因此需要更好的证据和指南。

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