The role of constitutive activation of FMS-related tyrosine kinase-3 and mutational status in infants with -rearranged acute lymphoblastic leukemia.
作者信息
Fedders Henning, Alsadeq Ameera, Schmäh Juliane, Vogiatzi Fotini, Zimmermann Martin, Möricke Anja, Lenk Lennart, Stadt Udo Zur, Horstmann Martin A, Pieters Rob, Schrappe Martin, Stanulla Martin, Cario Gunnar, Schewe Denis M
机构信息
Department of Pediatrics, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Pediatric Hematology and Oncology, Hannover Medical School, Germany.
出版信息
Haematologica. 2017 Nov;102(11):e438-e442. doi: 10.3324/haematol.2017.169870. Epub 2017 Aug 24.
Abstract
摘要
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The Biology and Targeting of FLT3 in Pediatric Leukemia.FLT3 在儿科白血病中的生物学和靶向治疗。
Front Oncol. 2014 Sep 23;4:263. doi: 10.3389/fonc.2014.00263. eCollection 2014.
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Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.Ph 样急性淋巴细胞白血病中可靶向的激酶激活病变。
N Engl J Med. 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088.
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Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia.FLT3 突变状态和表达水平在 MLL-AF4+ 和 MLL 胚系急性淋巴细胞白血病中的预后意义。
Leukemia. 2012 Nov;26(11):2360-6. doi: 10.1038/leu.2012.161. Epub 2012 Jun 18.
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Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.预测婴儿急性淋巴细胞白血病结局和年龄的基因表达谱：儿童肿瘤学组研究。
Blood. 2012 Feb 23;119(8):1872-81. doi: 10.1182/blood-2011-10-382861. Epub 2011 Dec 30.
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Prognostic significance of high-level FLT3 expression in MLL-rearranged infant acute lymphoblastic leukemia.MLL重排的婴儿急性淋巴细胞白血病中FLT3高表达的预后意义
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K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements.伴有或不伴有混合谱系白血病基因重排的儿童急性白血病中的K-Ras突变和N-Ras突变
Cancer. 2006 Feb 15;106(4):950-6. doi: 10.1002/cncr.21687.
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Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia.靶向原发性MLL基因重排的婴儿急性淋巴细胞白血病中的FLT3
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FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.酪氨酸激酶结构域激活环中的FLT3突变常见于伴有MLL重排的婴儿急性淋巴细胞白血病以及伴有超二倍体的儿童急性淋巴细胞白血病。
Blood. 2004 Feb 1;103(3):1085-8. doi: 10.1182/blood-2003-02-0418. Epub 2003 Sep 22.
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