Schockenhoff B, Daub D, Stadermann D, Hohaus J
Anaesthesist. 1987 Feb;36(2):69-72.
30 patients (ASA Class I-III) received opioid analgesia with fentanyl and alfentanil for extracorporeal shock wave lithotripsy. Average doses were 0.41 mg for fentanyl and 4.14 mg for alfentanil. Blood pressure, respiratory frequency, and blood gases were investigated postoperatively until the 240th min under spontaneous breathing of room air. Blood pressure varied less than 10% from initial values in both groups. The respiratory rate decreased by 13% in the alfentanil group and by 20% in the fentanyl group until the 120th min. The blood gases (paCO2, paO2) showed a slow increase of about 10% in the paCO2 in both groups. The paO2 lay at 5.8% below the baseline after 240 min in the fentanyl group and there was roughly 3% below the baseline after 60 min in the alfentanil group.
30例(ASA分级I - III级)患者接受芬太尼和阿芬太尼用于体外冲击波碎石术的阿片类镇痛。芬太尼平均剂量为0.41mg,阿芬太尼平均剂量为4.14mg。术后在室内空气自然呼吸状态下直至第240分钟,对血压、呼吸频率和血气进行了研究。两组血压与初始值相比变化均小于10%。直至第120分钟,阿芬太尼组呼吸频率下降了13%,芬太尼组下降了20%。两组血气(动脉血二氧化碳分压、动脉血氧分压)显示动脉血二氧化碳分压缓慢升高约10%。芬太尼组在240分钟后动脉血氧分压比基线低5.8%,阿芬太尼组在60分钟后比基线低约3%。