Shahzad Muhammad, Waqar Talal, Irfan Waheed Khawaja Ahmad, Gul Rafia, Fatima Syeda Tahseen
The Children's Hospital and the Institute of Child Health, Lahore.
Combined Military hospital, Rawalpindi.
J Pak Med Assoc. 2017 Aug;67(8):1220-1223.
To evaluate the effectiveness of pulse oximetry as a screening tool for critical congenital heart defects in newborns.
This cross-sectional study was conducted at the neonatology department of the Children's Hospital and the Institute of Child Health, Lahore, Pakistan, from January to June 2016, and comprised neonates aged up to 07 days. Babies with a prenatal diagnosis of heart defects and those whose parents refused to give consent were excluded. Oxygen saturation of enrolled patients was measured in right index finger (pre-ductal) and in the left big toe (post-ductal) subsequently. Echocardiography was done on all the enrolled babies to confirm the diagnosis. SPSS 19 was used for data analysis.
Of the 145 babies initially enrolled, 138(95.2%) were included. The overall mean age of the babies was 2.17±1.62 days (range: <24 hours-07 days) whereas the mean birth weight was 2.95±0.47kg (range: <2.5->4kg). Babies with pre- and post-ductal oxygen saturation measurement difference of >3% showed a detection rate of 16(45.7%) for critical congenital heart defects. Sensitivity and specificity of this screening test was calculated to be 76.19% and 83.76%, respectively, while positive and negative predictive values were 45.71% and 95.15%, respectively.
The measurement of pre- and post-ductal oxygen saturation by pulse oximetry was an effective screening tool for the detection of critical congenital heart defects in newborns.
评估脉搏血氧饱和度测定作为新生儿严重先天性心脏病筛查工具的有效性。
这项横断面研究于2016年1月至6月在巴基斯坦拉合尔儿童医院及儿童健康研究所新生儿科进行，纳入对象为年龄在7天及以内的新生儿。产前诊断为心脏缺陷的婴儿以及父母拒绝签署同意书的婴儿被排除。随后测量入选患者右手食指（导管前）和左大脚趾（导管后）的血氧饱和度。对所有入选婴儿进行超声心动图检查以确诊。使用SPSS 19进行数据分析。
最初入选的145名婴儿中，138名（95.2%）被纳入研究。婴儿的总体平均年龄为2.17±1.62天（范围：<24小时 - 7天），平均出生体重为2.95±0.47kg（范围：<2.5 -> 4kg）。导管前和导管后血氧饱和度测量差值>3%的婴儿中，严重先天性心脏病的检出率为16例（45.7%）。该筛查试验的敏感性和特异性分别计算为76.19%和83.76%，阳性预测值和阴性预测值分别为45.71%和95.15%。
通过脉搏血氧饱和度测定导管前和导管后的血氧饱和度是检测新生儿严重先天性心脏病的有效筛查工具。
