马来西亚高血压患者药物依从性评估及日历式泡罩包装干预相关成本：一项随机对照试验。
Assessment of medication adherence and the costs associated with a calendar blister pack intervention among hypertensive patients in Malaysia: A randomized controlled trial.
作者信息
Tan Bee Ying, Shafie Asrul Akmal, Hassali Mohamed Azmi Ahmad, Saleem Fahad
机构信息
Discipline of Social & Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan.
出版信息
SAGE Open Med. 2017 Aug 3;5:2050312117709189. doi: 10.1177/2050312117709189. eCollection 2017.
OBJECTIVES
To assess the efficacy and costs of a calendar blister packaging intervention used to improve medication adherence.
METHOD
A parallel randomized controlled trial was conducted with 73 hypertensive patients (intervention group = 35, control group = 38) at Hospital Kulim, Malaysia, for 7 months.
RESULTS
The intervention group demonstrated a significant improvement in medication possession ratio (p < 0.05) and percentage of on-time refills (p < 0.01) compared to control group. In addition, there was significantly lower blood pressure (p < 0.05) in intervention group. From the provider perspective, the average annual treatment cost per patient in the intervention group was MYR 2178.66 (USD 526.95) (95% confidence interval = 1786.39-2570.94) compared to MYR 2693.09 (USD 651.37) (95% confidence interval = 1903.23-3482.95) in the control group.
CONCLUSION
This study provides evidence that calendar blister packaging has a positive impact on medication adherence, blood pressure and also has the potential for considerable cost savings.
目的
评估用于提高药物依从性的日历泡罩包装干预措施的疗效和成本。
方法
在马来西亚居林医院对73名高血压患者进行了一项平行随机对照试验（干预组 = 35人，对照组 = 38人），为期7个月。
结果
与对照组相比，干预组的药物持有率（p < 0.05）和按时续方百分比（p < 0.01）有显著改善。此外，干预组的血压显著降低（p < 0.05）。从医疗服务提供者的角度来看，干预组每名患者的平均年度治疗成本为2178.66马来西亚林吉特（约合526.95美元）（95%置信区间 = 1786.39 - 2570.94），而对照组为2693.09马来西亚林吉特（约合651.37美元）（95%置信区间 = 1903.23 - 3482.95）。
结论
本研究提供了证据表明日历泡罩包装对药物依从性、血压有积极影响，并且具有可观的成本节约潜力。
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