光学相干断层扫描在外周肺动脉成像中的应用

Optical coherence tomography in imaging of peripheral pulmonary arteries.

作者信息

Hong Cheng, Zhong Nan-Shan, Liu Chun-Li, Zhang Nuo-Fu, Li Shi-Yue, Wang Wei

机构信息

Department of Respiratory, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, Guangzhou 510120, China.

Department of Cardiology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

出版信息

J Thorac Dis. 2017 Jul;9(7):1937-1944. doi: 10.21037/jtd.2017.06.66.

DOI:10.21037/jtd.2017.06.66

PMID:28839992

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5542995/

Abstract

BACKGROUND

To establish an optical coherence tomography (OCT)-based method for imaging peripheral pulmonary arteries.

METHODS

We recruited eight patients (five men; average age, 48±12 years; peripheral pulmonary artery thrombosis, three patients; idiopathic pulmonary hypertension, three patients; interstitial lung disease, two patients) who underwent OCT of the peripheral pulmonary arteries in the First Affiliated Hospital of Guangzhou Medical University and Guangzhou Institute of Respiratory Diseases, between September 2009 and September 2010. OCT was performed using both the conventional OCT imaging method (COI) and the improved pulmonary artery imaging method (IPI). In the IPI, contrast agent was used as an indicator of balloon inflation meanwhile increases in flushing speed of the replacement fluid. The percentage of optimal images, inflation pressure, flushing speeds and complications were compared between the two methods.

RESULTS

We performed OCT of 33 vessel segments by both methods. IPI produced more optimal images than COI (88% 24%). Mean inflation pressure and flushing speed were higher during IPI than COI (0.62±0.15 0.43±0.08 atm; 1 atm =101.3 kPa; 0.82±0.10 0.42±0.06 mL/s; both P<0.01). Decreased blood oxygen saturation (SaO2) was associated with 9% and 30% segments (P<0.01) in the COI (mean decrease, 8.4%±3.6%) and IPI groups (mean decrease, 12.1%±5.3%; P<0.05) respectively. SaO2 recovered to pre-imaging levels after oxygen inhalation.

CONCLUSIONS

IPI is safe and effective for OCT of peripheral pulmonary arteries.

摘要

背景

建立一种基于光学相干断层扫描（OCT）的外周肺动脉成像方法。

方法

我们招募了8例患者（5例男性；平均年龄48±12岁；外周肺动脉血栓形成3例；特发性肺动脉高压3例；间质性肺疾病2例），于2009年9月至2010年9月在广州医科大学附属第一医院和广州呼吸疾病研究所接受外周肺动脉OCT检查。采用传统OCT成像方法（COI）和改良肺动脉成像方法（IPI）进行OCT检查。在IPI中，使用造影剂作为球囊充盈的指标，同时提高置换液的冲洗速度。比较两种方法的最佳图像百分比、充盈压力、冲洗速度和并发症。

结果

两种方法均对33个血管节段进行了OCT检查。IPI产生的最佳图像比COI多（88%对24%）。IPI期间的平均充盈压力和冲洗速度高于COI（0.62±0.15对0.43±0.08 atm；1 atm = 101.3 kPa；0.82±0.10对0.42±0.06 mL/s；P均<0.01）。COI组和IPI组分别有9%和30%的节段血氧饱和度（SaO2）下降（P<0.01）（平均下降分别为8.4%±3.6%和12.1%±5.3%；P<0.05）。吸氧后SaO2恢复到成像前水平。