Dinan T G, Crunelli V, Kelly J S
Brain Res. 1987 Mar 24;407(1):159-62. doi: 10.1016/0006-8993(87)91231-5.
Intracellular recordings were made from pyramidal CA1-neurones of the hippocampal slice preparation. Bath application of a wide variety of neuroleptics was found to depress the slow afterhyperpolarization, which is mediated in these neurons by a calcium-dependent potassium conductance occurring following a burst of spikes. The depression of this conductance took place in the presence of calcium spikes of normal amplitude and duration, and except in the case of trifluoperazine, without alteration in resting membrane potential or input resistance.
在海马脑片制备物的锥体细胞CA1神经元上进行了细胞内记录。发现广泛应用的多种抗精神病药物浴用会抑制慢后超极化，在这些神经元中，慢后超极化是由一串动作电位后出现的钙依赖性钾电导介导的。这种电导的抑制在正常幅度和时程的钙峰存在时发生，除三氟拉嗪外，静息膜电位或输入电阻无改变。
