Chen Yangchun, Xie Si Pei, He Fang, Chen Jianwei
Department of Nuclear Medicine, First Hospital of Fujian Medical University, Quanzhou, China.
Department of Ultrasound, First Hospital of Fujian Medical University, Quanzhou, China.
Asia Ocean J Nucl Med Biol. 2017 Winter;5(1):44-48. doi: 10.22038/aojnmb.2016.7401.
In this study, we aimed to evaluate the efficacy of thyroid volume measurement using Tc pertechnetate single-photon emission computed tomography (SPECT) images, acquired by the standardized uptake value (SUV)-shape scheme designed by our expert team.
A total of 18 consecutive patients with Graves' disease (GD) were subjected to both ultrasonographic and Tc pertechnetate SPECT examinations of thyroid within a five-day interval. The volume of thyroid lobes and isthmus was measured by ultrasonography (US) according to the ellipsoid volume equation. The total thyroid volume, determined as the sum of the volume of both lobes and isthmus, was recorded as TV-US (i.e., thyroid volume measured by US) and set as the reference. The thyroid volume was defined according to our SUV-shape scheme and was recorded as TV-SS (i.e., thyroid volume determined by the SUV-shape scheme). The data were analyzed using the Bland-Altman plot, linear regression analysis, Spearman's rank correlation, and paired t-test, if necessary.
The values of TV-SS (40.2±29.4 mL) and TV-US (43.0±34.7 mL) were not significantly different (t=0.813; P=0.43). The linear regression equation of the two values was determined as TV-US= 1.072 × TV-SS - 0.29 (r=0.906; P<0.01).
The new scheme, i.e., SUV-shape scheme, exhibited potential for the measurement of thyroid volume in patients with GD.
在本研究中，我们旨在评估使用高锝酸盐单光子发射计算机断层扫描（SPECT）图像测量甲状腺体积的有效性，这些图像是通过我们专家团队设计的标准化摄取值（SUV）-形状方案获取的。
连续18例格雷夫斯病（GD）患者在五天内间隔接受甲状腺超声和高锝酸盐SPECT检查。根据椭球体体积公式，通过超声（US）测量甲状腺叶和峡部的体积。将两侧叶和峡部体积之和确定的总甲状腺体积记录为TV-US（即通过超声测量的甲状腺体积）并设定为参考值。根据我们的SUV-形状方案定义甲状腺体积，并记录为TV-SS（即通过SUV-形状方案确定的甲状腺体积）。如有必要，使用Bland-Altman图、线性回归分析、Spearman等级相关性和配对t检验对数据进行分析。
TV-SS（40.2±29.4 mL）和TV-US（43.0±34.7 mL）的值无显著差异（t = 0.813；P = 0.43）。这两个值的线性回归方程确定为TV-US = 1.072×TV-SS - 0.29（r = 0.906；P<0.01）。
新方案，即SUV-形状方案，在测量GD患者甲状腺体积方面显示出潜力。
