Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, China.
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Biomed Res Int. 2019 Jan 30;2019:7589853. doi: 10.1155/2019/7589853. eCollection 2019.
The clinical applications of the quantitative single photon emission computed tomography (SPECT)/computed tomography (CT) are being expanded to a variety of fields of nuclear medicine. However, clinical application of quantitative SPECT/CT for the evaluation of Graves' disease (GD) still needs further investigation. Our aim was to investigate the feasibility of standard uptake value (SUV) of the thyroid for the clinical diagnosis and evaluation of GD. In this prospective multicenter study, 116 patients diagnosed with GD (Graves group) and 74 healthy volunteers (control group) were enrolled from 8 different hospitals. All patients underwent technetium pertechnetate (TcO ) SPECT/CT imaging with Q.Metrix quantitative software and 24-hour thyroid radioactive iodine uptake (24h-RAIU) test. The SUVmax and SUVmean in Graves group were significantly higher than those of control group (<0.01). Cut-off values of SUVmax and SUVmean to predict GD were 231.425 and 116.66 by ROC curves, respectively. The SUVmax and SUVmean in Graves patients were significantly related to serum thyroxine level with correlation coefficient of 0.493 and 0.512 for FT and 0.449 and 0.464 for FT, respectively (all <0.01). Additionally, the SUVmax and SUVmean in GD positively correlated with 24h-RAIU with a coefficient of 0.832 and 0.830, respectively (<0.01). The volumes determined by Q.Metrix (35.65 ± 20.56ml) of 72 subjects also positively correlated with that from ultrasound (36.67 ± 21.00ml) with a coefficient of 0.927 (<0.01). SUV measurements derived from thyroid SPECT/CT may be useful for the clinical diagnosis and evaluation of GD.
甲状腺定量单光子发射型计算机断层扫描（SPECT）/计算机断层扫描（CT）的临床应用正在扩展到核医学的各个领域。然而，定量 SPECT/CT 在 Graves 病（GD）评估中的临床应用仍需要进一步研究。我们的目的是探讨甲状腺摄取比值（SUV）在 GD 临床诊断和评估中的可行性。在这项前瞻性多中心研究中，我们从 8 家不同的医院招募了 116 名诊断为 GD（Graves 组）的患者和 74 名健康志愿者（对照组）。所有患者均接受锝（TcO ）SPECT/CT 成像，使用 Q.Metrix 定量软件和 24 小时甲状腺放射性碘摄取（24h-RAIU）试验。Graves 组的 SUVmax 和 SUVmean 明显高于对照组（<0.01）。ROC 曲线分析得到 SUVmax 和 SUVmean 预测 GD 的截断值分别为 231.425 和 116.66。Graves 患者的 SUVmax 和 SUVmean 与血清甲状腺素水平显著相关，FT 与 FT 的相关系数分别为 0.493 和 0.512（均<0.01）。此外，SUVmax 和 SUVmean 与 24h-RAIU 呈正相关，相关系数分别为 0.832 和 0.830（<0.01）。72 例患者的 Q.Metrix 测量体积（35.65±20.56ml）也与超声测量体积（36.67±21.00ml）呈正相关，相关系数为 0.927（<0.01）。甲状腺 SPECT/CT 测量的 SUV 值可能有助于 GD 的临床诊断和评估。
