Schneiderman J H, MacDonald J F
Brain Res. 1987 Apr 28;410(1):174-8. doi: 10.1016/s0006-8993(87)80042-2.
Spontaneous, synchronous burst discharges originating in the CA2-CA3 region of guinea pig hippocampal slices occur when the concentration of magnesium in the perfusate is reduced below 250 microM. The burst frequency is greater than that seen with other convulsants and afterdischarge is common. Cyclic periods of bursting resembling ictal discharges occur spontaneously in some slices and with repetitive stimulation (0.5-2 Hz) in most slices. The spontaneous bursts are blocked by 2-APV suggesting the involvement of NMDA receptors in their generation.
当灌流液中镁离子浓度降低至250微摩尔以下时，豚鼠海马脑片CA2-CA3区会出现自发的同步爆发性放电。爆发频率高于其他惊厥剂引起的频率，且常见后放电现象。在一些脑片中会自发出现类似发作性放电的周期性爆发，在大多数脑片中经重复刺激（0.5 - 2赫兹）也会出现。2-氨基-5-磷酰戊酸可阻断自发爆发，提示NMDA受体参与其产生过程。
