Zhang Shumin, Yang Qin, Guo Lin, Zhang Ying, Feng Lingling, Zhou Ling, Yang Shengxiang, Yao Qingshou, Pescitelli Gennaro, Xie Zeping
School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Chem Commun (Camb). 2017 Sep 5;53(72):10066-10069. doi: 10.1039/c7cc04983h.
Three pairs of new enantiomeric alkaloids with an unprecedented spiro indolinone-naphthofuran skeleton were isolated from a marine Streptomyces sp. The pure enantiomers had a marked difference in the enantiomerization processes for the three compounds. DFT calculations in combination with chemical derivatization were performed to corroborate the racemization process via a keto-enol-type tautomerism.
从一株海洋链霉菌中分离出三对具有前所未有的螺吲哚啉酮-萘并呋喃骨架的新对映体生物碱。这三种化合物的纯对映体在对映异构化过程中存在显著差异。结合化学衍生化进行了密度泛函理论（DFT）计算，以证实通过酮-烯醇型互变异构的外消旋化过程。
