Diabetes Center, 2nd Department of Medicine, Faculty Hospital Kralovske Vinohrady, Charles University 3rd Faculty of Medicine, Prague, Czech Republic.
Dubrava University Hospital, Zagreb, Croatia.
Diabetes Metab Res Rev. 2018 Jan;34(1). doi: 10.1002/dmrr.2940. Epub 2017 Sep 29.
MODY (maturity-onset diabetes of the young) is a genetically linked group of clinically heterogeneous subtypes of diabetes. Roughly 5% of people with diabetes mellitus diagnosed prior to age 45 have MODY diabetes. Most of them have been erroneously diagnosed as patients with either type 1 or type 2 diabetes and, as a result, have been improperly treated. Genetic identification of MODY diabetes and its subtypes allows proper treatment and enables clinicians to switch many patients to oral antidiabetic agents, mainly sulphonylureas. However, some new classes of oral antidiabetic drugs have also been tested and found to be effective in MODY patients. We have searched for research articles and case reports written in full-text English or with an English abstract, using the following keywords: MODY and oral antidiabetic* in the databases Cochrane Library, PubMed, and Science Direct. Therapeutic options using currently standardized oral antidiabetic drugs (mainly sulphonylureas), as well as more experimental treatment with other classes of oral antidiabetic drugs in different types of MODY, are discussed, with special focus on the therapy of the most common MODY subtypes, including specific conditions such as pregnancy. This review article summarizes the currently available information about oral antidiabetic treatment of patients with MODY diabetes.
MODY（年轻起病的成人型糖尿病）是一组与遗传相关的、临床上具有异质性的糖尿病亚型。大约 5%在 45 岁之前被诊断为糖尿病的患者患有 MODY 糖尿病。他们中的大多数被错误地诊断为 1 型或 2 型糖尿病患者，因此治疗不当。MODY 糖尿病及其亚型的基因鉴定可实现正确治疗，并使临床医生能够将许多患者切换为口服抗糖尿病药物，主要是磺酰脲类。然而，一些新类别的口服抗糖尿病药物也已被测试并发现对 MODY 患者有效。我们在 Cochrane 图书馆、PubMed 和 Science Direct 数据库中，使用以下关键字搜索了全文为英文或附有英文摘要的研究文章和病例报告：MODY 和口服抗糖尿病*。讨论了使用当前标准化的口服抗糖尿病药物（主要是磺酰脲类）的治疗选择，以及在不同类型的 MODY 中使用其他类别的口服抗糖尿病药物进行更具实验性的治疗，特别关注最常见的 MODY 亚型的治疗，包括妊娠等特殊情况。这篇综述文章总结了目前关于 MODY 糖尿病患者口服抗糖尿病治疗的可用信息。
