• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Highly Aggressive de novo Aleukemic Variant of Mast Cell Leukemia Without KIT D816V Mutation.

作者信息

Suh Myung Chul, Ham Ji Yeon, Park Tae In, Moon Joon Ho, Suh Jang Soo

机构信息

Department of Laboratory Medicine, Kyungpook National University Hospital, Daegu, Korea.

Department of Pathology, Kyungpook National University Hospital, Daegu, Korea.

出版信息

Ann Lab Med. 2017 Nov;37(6):547-549. doi: 10.3343/alm.2017.37.6.547.

DOI:10.3343/alm.2017.37.6.547
PMID:28840997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5587832/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/871b/5587832/076878f98f40/alm-37-547-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/871b/5587832/1a903f0c7893/alm-37-547-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/871b/5587832/076878f98f40/alm-37-547-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/871b/5587832/1a903f0c7893/alm-37-547-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/871b/5587832/076878f98f40/alm-37-547-g002.jpg

相似文献

1
Highly Aggressive de novo Aleukemic Variant of Mast Cell Leukemia Without KIT D816V Mutation.无KIT D816V突变的高度侵袭性原发性无白血病性肥大细胞白血病变异型
Ann Lab Med. 2017 Nov;37(6):547-549. doi: 10.3343/alm.2017.37.6.547.
2
Aleukemic mast cell leukemia with abnormal immunophenotype and c-kit mutation D816V.伴有异常免疫表型和c-kit基因D816V突变的无白血病性肥大细胞白血病
Leuk Lymphoma. 2004 Nov;45(11):2295-302. doi: 10.1080/10428190412331272695.
3
De novo leukemic variant of mast cell leukemia with KIT D816V.伴有KIT D816V突变的肥大细胞白血病的新发白血病变异型。
Ann Lab Med. 2015 Mar;35(2):260-2. doi: 10.3343/alm.2015.35.2.260. Epub 2015 Feb 12.
4
De novo mast cell leukemia without CD25 expression and KIT mutations: a rare case report in a 13-year-old child.无CD25表达及KIT突变的原发性肥大细胞白血病：一名13岁儿童的罕见病例报告
Diagn Pathol. 2018 Feb 20;13(1):14. doi: 10.1186/s13000-018-0691-2.
5
A case of de novo aleukemic mast cell leukemia without c-KIT mutations in exons 8 and 17.一例8号和17号外显子无c-KIT突变的初发性无白血病性肥大细胞白血病病例。
Int J Lab Hematol. 2014 Aug;36(4):e44-6. doi: 10.1111/ijlh.12147. Epub 2013 Sep 6.
6
PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects.PKC412抑制表达KIT基因D816V突变变体的人肿瘤性肥大细胞的体外生长：与AMN107、伊马替尼和克拉屈滨（2CdA）比较及联合用药效果评估。
Blood. 2006 Jan 15;107(2):752-9. doi: 10.1182/blood-2005-07-3022. Epub 2005 Sep 27.
7
Mastocytosis: state of the art.肥大细胞增多症：最新进展
Pathobiology. 2007;74(2):121-32. doi: 10.1159/000101711.
8
Utility of flow cytometric analysis of mast cells in the diagnosis and classification of adult mastocytosis.肥大细胞的流式细胞术分析在成人肥大细胞增多症诊断和分类中的应用
Leuk Res. 2001 Jul;25(7):563-70. doi: 10.1016/s0145-2126(01)00050-9.
9
Mastocytosis and related disorders.肥大细胞病及相关疾病。
Semin Diagn Pathol. 2012 Feb;29(1):19-30. doi: 10.1053/j.semdp.2011.06.002.
10
Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor.肥大细胞白血病：鉴定一种新的 c-Kit 突变，dup(501-502)，以及对 c-Kit 酪氨酸激酶抑制剂 masitinib 的反应。
Eur J Haematol. 2012 Jul;89(1):47-52. doi: 10.1111/j.1600-0609.2012.01761.x. Epub 2012 Apr 28.

引用本文的文献

1
Case report: Experience of a rare case of primary acute mast cell leukemia.病例报告：一例原发性急性肥大细胞白血病罕见病例的诊疗经验
Leuk Res Rep. 2025 Apr 12;23:100510. doi: 10.1016/j.lrr.2025.100510. eCollection 2025.
2
Mast Cell Leukemia: An Update with a Practical Review.肥大细胞白血病：最新进展与实用综述
Cancers (Basel). 2023 Mar 8;15(6):1664. doi: 10.3390/cancers15061664.
3
Acute aleukemic mast cell leukemia: Report of a case and review of the literature.急性无白细胞性肥大细胞白血病：一例报告并文献复习

本文引用的文献

1
Mast Cells, Mastocytosis, and Related Disorders.肥大细胞、肥大细胞增多症及相关疾病
N Engl J Med. 2015 Jul 9;373(2):163-72. doi: 10.1056/NEJMra1409760.
2
Serum total tryptase level confirms itself as a more reliable marker of mast cells burden in mast cell leukaemia (aleukaemic variant).血清总类胰蛋白酶水平证实自身是肥大细胞白血病（无白血病变异型）中肥大细胞负荷更可靠的标志物。
Case Rep Hematol. 2015;2015:737302. doi: 10.1155/2015/737302. Epub 2015 Feb 10.
3
Mast cell leukemia.肥大细胞白血病。
Leuk Res Rep. 2020 Nov 26;14:100230. doi: 10.1016/j.lrr.2020.100230. eCollection 2020.
4
Mast Cell Leukemia with Ascites and Multiple Organs Damage.伴有腹水和多器官损害的肥大细胞白血病
Iran J Pathol. 2019 Summer;14(3):265-269. doi: 10.30699/ijp.2019.96187.1948. Epub 2019 Aug 1.
Blood. 2013 Feb 21;121(8):1285-95. doi: 10.1182/blood-2012-07-442400. Epub 2012 Dec 14.
4
Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors.342例连续成年系统性肥大细胞增多症患者的生存研究及预后因素
Blood. 2009 Jun 4;113(23):5727-36. doi: 10.1182/blood-2009-02-205237. Epub 2009 Apr 10.
5
Immunohistochemical assessment of CD25 is equally sensitive and diagnostic in mastocytosis compared to flow cytometry.与流式细胞术相比，CD25的免疫组织化学评估在肥大细胞增多症中同样敏感且具有诊断价值。
Eur J Clin Invest. 2008 May;38(5):326-35. doi: 10.1111/j.1365-2362.2008.01942.x. Epub 2008 Mar 20.
6
Mast cell leukemia: a report of ten cases.
Ann Hematol. 2008 Jun;87(6):505-8. doi: 10.1007/s00277-007-0430-3. Epub 2008 Jan 3.
7
Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria.肥大细胞增多症的标准与标准化：关于诊断、治疗建议及反应标准的共识声明
Eur J Clin Invest. 2007 Jun;37(6):435-53. doi: 10.1111/j.1365-2362.2007.01807.x.
8
Aleukemic mast cell leukemia with abnormal immunophenotype and c-kit mutation D816V.伴有异常免疫表型和c-kit基因D816V突变的无白血病性肥大细胞白血病
Leuk Lymphoma. 2004 Nov;45(11):2295-302. doi: 10.1080/10428190412331272695.
9
Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis.肿瘤性肥大细胞的形态学特性：成熟阶段的界定及对肥大细胞增多症细胞学分级的意义
Leuk Res. 2001 Jul;25(7):529-36. doi: 10.1016/s0145-2126(01)00041-8.