Nakamura M, Ferreira S H
Eur J Pharmacol. 1987 Mar 17;135(2):145-53. doi: 10.1016/0014-2999(87)90606-6.
Non-steroidal anti-inflammatory drugs (NSAID) only partially inhibit the hyperalgesia in the inflammation induced by carrageenin in the hind rat paw, one of the most frequently used nociceptive tests. We now report that either the guanethidine depletion of peripheral sympathomimetic amines or the treatment with adrenoceptor antagonists (beta-blockers) and a specific dopamine (DA)-1 antagonist (SCH 23390) significantly reduced carrageenin hyperalgesia. These antagonists also abolished the rat paw hyperalgesia induced by several sympathomimetic amines as well as that induced by a selective DA-1 agonist, SKF 38393. Blockade of uptake-1 by cocaine potentiated the hyperalgesia induced by carrageenin and sympathomimetic amines. We conclude that there is a sympathetic component, possibly mediated by a DA-1 type receptor in carrageenin-induced hyperalgesia. This component may predominate in certain types of pain not sensitive to NSAID. If so, selective peripheral DA-1 antagonists could be developed as a novel class of analgesics.
非甾体抗炎药（NSAID）仅能部分抑制角叉菜胶诱导的大鼠后爪炎症中的痛觉过敏，这是最常用的伤害性感受测试之一。我们现在报告，外周拟交感胺的胍乙啶耗竭或用肾上腺素能受体拮抗剂（β受体阻滞剂）和特异性多巴胺（DA）-1拮抗剂（SCH 23390）治疗可显著减轻角叉菜胶诱导的痛觉过敏。这些拮抗剂还消除了几种拟交感胺诱导的大鼠爪痛觉过敏以及选择性DA-1激动剂SKF 38393诱导的痛觉过敏。可卡因对摄取-1的阻断增强了角叉菜胶和拟交感胺诱导的痛觉过敏。我们得出结论，在角叉菜胶诱导的痛觉过敏中存在一个交感神经成分，可能由DA-1型受体介导。该成分可能在某些对NSAID不敏感的疼痛类型中占主导。如果是这样，选择性外周DA-1拮抗剂可被开发为一类新型镇痛药。
