Brown D L, Hogue D E
J Dairy Sci. 1987 Apr;70(4):823-30. doi: 10.3168/jds.S0022-0302(87)80079-6.
These trials explored metabolic events associated with monensin-induced changes in milk composition. In trial 1, diets containing 0 or 33 ppm monensin sodium were fed ad libitum to separate groups of 7 mature lactating goats. In trial 2, diets containing 0 or 18 ppm monensin sodium were fed ad libitum to two groups with 5 mature (greater than 2 yr) and seven young (less than 2 yr) lactating does in each group. Blood was sampled at 1200 h and at 3 min after morning milking in both trials. Diets containing 33 ppm monensin increased serum growth hormone and plasma glucagon. Monensin (33 ppm) increased growth hormone from 13 to 60 ng/ml in samples taken 3 min after milking. Monensin (33 ppm) decreased insulin in these postmilking samples from 432 to 317 pg/ml but increased midday insulin in the samples taken between milkings from 279 to 349 pg/ml. Monensin did not affect plasma glucose or serum prolactin concentrations. Monensin fed at 18 ppm did not affect growth hormone, glucagon, adipose acetyl CoA carboxylase activity, hormone-sensitive lipase, or glucose concentrations. Young animals had higher growth hormone, glucose, and glucagon than mature does. The results indicate that effects of milk production intensity can be more important than monensin treatment on milk composition and circulating hormone concentrations.
这些试验探究了与莫能菌素诱导的牛奶成分变化相关的代谢事件。在试验1中，将含0或33 ppm莫能菌素钠的日粮随意投喂给7只成年泌乳山羊的不同分组。在试验2中，将含0或18 ppm莫能菌素钠的日粮随意投喂给两组，每组分别有5只成年（大于2岁）和7只幼年（小于2岁）泌乳母羊。在两个试验中，均于12:00以及早晨挤奶后3分钟采集血液样本。含33 ppm莫能菌素的日粮可提高血清生长激素和血浆胰高血糖素水平。莫能菌素（33 ppm）使挤奶后3分钟采集的样本中生长激素水平从13 ng/ml升至60 ng/ml。莫能菌素（33 ppm）使这些挤奶后样本中的胰岛素水平从432 pg/ml降至317 pg/ml，但使挤奶间隔期采集的样本中午胰岛素水平从279 pg/ml升至349 pg/ml。莫能菌素不影响血浆葡萄糖或血清催乳素浓度。投喂18 ppm的莫能菌素不影响生长激素、胰高血糖素、脂肪组织乙酰辅酶A羧化酶活性、激素敏感性脂肪酶或葡萄糖浓度。幼年动物的生长激素、葡萄糖和胰高血糖素水平高于成年母羊。结果表明，就牛奶成分和循环激素浓度而言，产奶强度的影响可能比莫能菌素处理更为重要。
