Ratcliffe J H, Hunneyball I M, Wilson C G, Smith A, Davis S S
J Pharm Pharmacol. 1987 Apr;39(4):290-5. doi: 10.1111/j.2042-7158.1987.tb06268.x.
The retention of 131I-labelled albumin microspheres and microsphere-entrapped [131I]rose bengal was investigated in normal and experimentally arthritic knee joints of rabbits. Albumin microspheres were cleared slowly from the joint cavity and no significant difference was observed between normal and inflamed joints. Entrapment of rose bengal within albumin microspheres was found to delay the clearance of the drug from the joint when compared with a solution of rose bengal. In addition, the retention time for entrapped rose bengal was dependent on the degree of inflammation present.
在正常和实验性关节炎兔膝关节中研究了131I标记的白蛋白微球和包裹有[131I]孟加拉玫瑰红的微球的滞留情况。白蛋白微球从关节腔清除缓慢，正常关节和发炎关节之间未观察到显著差异。与孟加拉玫瑰红溶液相比，发现白蛋白微球中包裹的孟加拉玫瑰红会延迟药物从关节的清除。此外，包裹的孟加拉玫瑰红的滞留时间取决于存在的炎症程度。
