由包衣乳糖粉制成的片剂的溶出机制。
Dissolution mechanism of tablets produced from coated lactose powder.
作者信息
Igwilo C, Pilpel N
出版信息
J Pharm Pharmacol. 1987 Apr;39(4):301-2. doi: 10.1111/j.2042-7158.1987.tb06270.x.
Abstract
The use of the equation of Kitazawa et al in the analysis of the dissolution process of tablets produced from lactose powder coated with paraffin has suggested either an initial breaking of the tablets into particles that subsequently break down into smaller particles or a progressive breaking of the tablet into smaller particles. The former produces a change in rate constant from k1 to k2.
摘要
在分析由涂有石蜡的乳糖粉末制成的片剂的溶出过程中，使用北泽等人的方程表明，要么片剂最初破碎成颗粒，随后这些颗粒再分解成更小的颗粒，要么片剂逐渐破碎成更小的颗粒。前者会使速率常数从k1变为k2。
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