乌头碱对豚鼠输精管收缩反应的增强作用及组织钠含量的增加
Potentiation of contractile response and increase in tissue sodium content induced by aconitine in the guinea-pig vas deferens.
作者信息
Ohizumi Y, Kajiwara A
出版信息
J Pharm Pharmacol. 1987 Apr;39(4):324-6. doi: 10.1111/j.2042-7158.1987.tb06280.x.
Abstract
Aconitine potentiated the contractile response of the guinea-pig vas deferens and increased the tissue Na and Ca content. These effects were abolished in the presence of tetrodotoxin. These results suggest that aconitine causes an increasing Na+ permeability of the smooth muscle membrane to increase Ca2+ availability and thus induces potentiation.
摘要
乌头碱增强了豚鼠输精管的收缩反应，并增加了组织中的钠和钙含量。在存在河豚毒素的情况下，这些作用被消除。这些结果表明，乌头碱使平滑肌膜的钠通透性增加，以增加钙离子的可用性，从而诱导增强作用。
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