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豚鼠输精管平滑肌对去甲肾上腺素的电反应和机械反应所需的细胞外钙和钠

Requirements of external Ca and Na for the electrical and mechanical responses to noradrenaline in the smooth muscle of guinea-pig vas deferens.

作者信息

Wakui M, Inomata H

出版信息

Jpn J Physiol. 1984;34(1):199-203. doi: 10.2170/jjphysiol.34.199.

DOI:10.2170/jjphysiol.34.199
PMID:6328079
Abstract

Noradrenaline (NA) evoked a contraction which consisted of two components, an initial one associated with only depolarization and a second one with spike discharges. Both contractions were abolished in a Ca-free solution leaving only small depolarization. In a Na-free solution, the initial contraction was increased in keeping with the short term depolarization, while the second contraction was abolished. It is suggested that NA initially causes Ca influx which secondarily increases Na permeability.

摘要

去甲肾上腺素(NA)引发了一种收缩,该收缩由两个部分组成,一个初始部分仅与去极化相关,另一个部分与动作电位发放相关。在无钙溶液中,两种收缩均被消除,仅留下小的去极化。在无钠溶液中,初始收缩随着短期去极化而增强,而第二种收缩被消除。提示NA最初引起钙内流,继而增加钠通透性。

相似文献

1
Requirements of external Ca and Na for the electrical and mechanical responses to noradrenaline in the smooth muscle of guinea-pig vas deferens.豚鼠输精管平滑肌对去甲肾上腺素的电反应和机械反应所需的细胞外钙和钠
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引用本文的文献

1
Decrease in membrane conductance induced by noradrenaline in the smooth muscle of guinea-pig vas deferens.去甲肾上腺素引起的豚鼠输精管平滑肌膜电导降低。
Pflugers Arch. 1985 Jan;403(1):109-11. doi: 10.1007/BF00583290.
2
Dual excitatory actions of acetylcholine at the neuromuscular junction in the guinea-pig vas deferens.乙酰胆碱在豚鼠输精管神经肌肉接头处的双重兴奋作用。
Pflugers Arch. 1986 Jun;406(6):587-93. doi: 10.1007/BF00584025.