神经纤毛蛋白-2在免疫系统中的作用。

Role of neuropilin-2 in the immune system.

作者信息

Schellenburg S, Schulz A, Poitz D M, Muders M H

机构信息

Institute of Pathology, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany.

Department of Internal Medicine and Cardiology, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany.

出版信息

Mol Immunol. 2017 Oct;90:239-244. doi: 10.1016/j.molimm.2017.08.010. Epub 2017 Aug 30.

DOI:10.1016/j.molimm.2017.08.010

PMID:28843905

Abstract

Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). They are up to 44 % homologous and conserved in all vertebrates. High levels of NRP2 are found on immune cells. Current research is very limited regarding the functions of NRP2 on these cells. Recent evidence suggests that NRP2 is important for migration, antigen presentation, phagocytosis and cell-cell contact within the immune system. Additionally, posttranslational NRP2 modifications like polysialylation are crucial for the function of some immune cells. This review is an overview about expression and functions of NRP2 in the immune system.

摘要

神经纤毛蛋白（NRPs）是具有短细胞质尾巴的单跨膜受体，其信号转导依赖于血管内皮生长因子受体（VEGF受体）或丛状蛋白等受体。已知NRPs在血管生成、淋巴管生成和轴突导向中起重要作用。神经纤毛蛋白家族由两个成员组成，即神经纤毛蛋白-1（NRP1）和神经纤毛蛋白-2（NRP2）。它们在所有脊椎动物中同源性高达44%且保守。在免疫细胞上发现高水平的NRP2。目前关于NRP2在这些细胞上功能的研究非常有限。最近的证据表明，NRP2对免疫系统内的迁移、抗原呈递、吞噬作用和细胞间接触很重要。此外，像多唾液酸化这样的NRP2翻译后修饰对某些免疫细胞的功能至关重要。本综述是关于NRP2在免疫系统中的表达和功能的概述。