Department of Hematology, the Second Affiliated Hospital of Anhui Medical University, Heifei, China.
Department of Hematology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
Lipids Health Dis. 2024 Sep 16;23(1):299. doi: 10.1186/s12944-024-02289-5.
Lipid levels have been suggset to be correlated with multiple myeloma (MM) risk, though causality remains unconfirmed. To explore this further, a detailed study combining meta-analysis and Mendelian randomization (MR) was conducted.
Literature searches were performed on PubMed and Embase; summary data for plasma lipid traits were extracted from the IEU and MM data from the FinnGen database. Meta-analysis and MR were utilized to analyze the link of lipids with MM risk, including mediator MR to identify potential mediators. The study was conducted in accordance with PRISMA and STROBE-MR guidelines.
Observational studies analyzed through meta-analysis showed that elevated levels of LDL, HDL, total cholesterol (TC), and triglycerides correlate with a lower risk of MM, with HRs of 0.73, 0.59, 0.60, and 0.84, respectively. MR analysis confirmed a potential causal link of triglyceride with a reduced MM risk (OR: 0.67, 95% CI: 0.46-0.98), independent of BMI. Mediation analysis pointed to X-11,423-O-sulfo-L-tyrosine and neuropilin-2 as potential mediators.
The findings suggest that higher lipid levels (LDL, HDL, TC, and triglycerides) are linked with a reduced MM risk, and higher triglyceride levels are causally associated with a reduced MM risk. This suggests new avenues for therapeutic interventions targeting MM.
血脂水平与多发性骨髓瘤（MM）风险相关，但因果关系尚未得到证实。为了进一步探讨这一问题，我们进行了一项详细的研究，结合荟萃分析和孟德尔随机化（MR）进行分析。
在 PubMed 和 Embase 上进行文献检索；从 IEU 和 FinnGen 数据库中的 MM 数据中提取血浆脂质特征的汇总数据。使用荟萃分析和 MR 分析脂质与 MM 风险的关联，包括中介 MR 以确定潜在的中介物。该研究按照 PRISMA 和 STROBE-MR 指南进行。
通过荟萃分析分析的观察性研究表明，升高的 LDL、HDL、总胆固醇（TC）和甘油三酯水平与 MM 风险降低相关，HR 分别为 0.73、0.59、0.60 和 0.84。MR 分析证实甘油三酯与 MM 风险降低之间存在潜在的因果关系（OR：0.67，95%CI：0.46-0.98），与 BMI 无关。中介分析表明 X-11,423-O-磺酸-L-酪氨酸和神经纤毛蛋白-2可能是潜在的中介物。
研究结果表明，较高的脂质水平（LDL、HDL、TC 和甘油三酯）与 MM 风险降低相关，较高的甘油三酯水平与 MM 风险降低呈因果关系。这为针对 MM 的治疗干预提供了新的途径。
