Andrology Department, Cairo University Hospitals, Cairo, Egypt.
Andrology Department, Cairo University Hospitals, Cairo, Egypt; Andrology Department, University College London Hospital, London, UK.
Sex Med Rev. 2018 Jan;6(1):135-142. doi: 10.1016/j.sxmr.2017.07.008. Epub 2017 Aug 23.
Botulinum toxin type A (BoNT-A) has been used to treat several striated and smooth muscle disorders. During the past year, human and animal studies conducted in Egypt and Canada by two different groups of investigators have suggested a possible role for the intracavernosal injection of BoNT-A in the treatment of erectile dysfunction (ED).
To discuss BoNT-A and its current medical uses, the rationale for its new potential use in the treatment of ED, and the available evidence and concerns.
A literature search was conducted. This review was based on the available studies presented at the European Society for Sexual Medicine, Sexual Medicine Society of North America, and International Society for Sexual Medicine meetings in 2016 by the two groups.
Sinusoidal diameter; penile color Doppler study; Erection Hardness Score; Sexual Health Inventory for Men questionnaire; and Sexual Encounter Profile questions 2 and 3.
Two human studies conducted by the authors and two animal studies (one from the authors' group and one from Canada) were reviewed. These seemed to suggest generally favorable outcomes with the use of BoNT-A in the treatment of ED.
BoNT-A could be a potential therapy for ED. In addition to the findings of the three pilot studies, larger multicenter trials need to be conducted to further explore the true therapeutic efficacy and clinical safety of BoNT-A in the treatment of ED. Ghanem H, Raheem AA, AbdelRahman IFS, et al. Botulinum Neurotoxin and Its Potential Role in the Treatment of Erectile Dysfunction. Sex Med Rev 2018;6:135-142.
A型肉毒毒素（BoNT-A）已被用于治疗多种横纹肌和平滑肌疾病。在过去的一年中，埃及和加拿大的两个不同研究小组进行的人体和动物研究表明，在阴茎海绵体内注射 BoNT-A 可能在治疗勃起功能障碍（ED）方面具有一定作用。
讨论 BoNT-A 及其当前的医学用途，探讨其在 ED 治疗中的新的潜在用途的基本原理，以及现有的证据和关注点。
进行了文献检索。本综述基于 2016 年欧洲性医学学会、北美性医学学会和国际性医学学会会议上两个小组发表的现有研究。
海绵体窦直径；阴茎彩色多普勒研究；勃起硬度评分；男性性健康问卷；性遭遇概况问卷 2 和 3。
作者进行了两项人体研究和两项动物研究（一项来自作者小组，一项来自加拿大），这些研究似乎表明 BoNT-A 治疗 ED 的总体效果良好。
BoNT-A 可能是 ED 的一种潜在治疗方法。除了三项初步研究的结果外，还需要进行更大规模的多中心试验，以进一步探讨 BoNT-A 在治疗 ED 中的真正治疗效果和临床安全性。Ghanem H、Raheem AA、AbdelRahman IFS 等。肉毒神经毒素及其在治疗勃起功能障碍中的潜在作用。性医学评论 2018；6:135-142。
