Chen Yao, Zhu Beibei, Wu Xiaoyan, Li Si, Tao Fangbiao
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, China.
BMJ Open. 2017 Aug 27;7(8):e016404. doi: 10.1136/bmjopen-2017-016404.
To determine whether maternal vitamin D deficiency during pregnancy is associated with small for gestational age (SGA).
A comprehensive literature search of PubMed, the Cochrane Library, Embase, and the Elsevier ScienceDirect library was conducted to identify relevant articles reporting prospective cohort studies in English, with the last report included published in February 2017. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to evaluate the correlation in a random effects model.
A total of 13 cohort studies were included in this meta-analysis with a sample of 28 285 individuals from seven countries. The pooled overall OR for babies born SGA was 1.588 ( CI 1.138 to 2.216; p0.01) for women with vitamin D deficiency. The prevalence of vitamin D deficiency during pregnancy varied from 13.2% to 77.3%. Subgroup analyses identified no significant differences in the association between vitamin D deficiency and SGA based on study quality, gestational week during which blood sampling was performed, cut-off vitamin D levels, sample size, adjustment for critical confounders and method for measuring vitamin D.
This meta-analysis suggests that vitamin D deficiency is associated with an increased risk of SGA.
确定孕期母亲维生素D缺乏是否与小于胎龄儿（SGA）有关。
对PubMed、Cochrane图书馆、Embase和爱思唯尔ScienceDirect图书馆进行全面文献检索，以识别用英文报道前瞻性队列研究的相关文章，纳入的最后一篇报道发表于2017年2月。采用合并比值比（OR）和相应的95%置信区间（CI）在随机效应模型中评估相关性。
本荟萃分析共纳入13项队列研究，样本来自7个国家，共28285人。维生素D缺乏的女性所生小于胎龄儿的合并总体OR为1.588（CI 1.138至2.216；P<0.01）。孕期维生素D缺乏的患病率在13.2%至77.3%之间。亚组分析未发现基于研究质量、采血时的孕周、维生素D水平临界值、样本量、关键混杂因素调整及维生素D测量方法的维生素D缺乏与小于胎龄儿之间的关联存在显著差异。
本荟萃分析表明，维生素D缺乏与小于胎龄儿风险增加有关。
