Dong Bo, Zhou Shenghua, Yu Siyang, Tang Liang
Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Jul 28;42(7):848-853. doi: 10.11817/j.issn.1672-7347.2017.07.018.
Myocardial ischemia-reperfusion injury (MI/RI) is an inflammatory cascade process involving the interaction of multiple factors. In recent years, more and more evidence suggests that NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome, an important component of the innate immune system, is closely associated with the inflammatory damage of MI/RI. Furthermore, blockage of NLRP3 inflammasome or the release of its downstream pro-inflammatory cytokines may provide new therapeutic targets for this disorder.
心肌缺血再灌注损伤（MI/RI）是一个涉及多种因素相互作用的炎症级联反应过程。近年来，越来越多的证据表明，核苷酸结合寡聚化结构域样受体含pyrin结构域3（NLRP3）炎性小体作为固有免疫系统的重要组成部分，与MI/RI的炎症损伤密切相关。此外，阻断NLRP3炎性小体或其下游促炎细胞因子的释放可能为该疾病提供新的治疗靶点。
